Para ler as justificativas, clique aqui.
| – | TIME | POSIÇÃO | NOME | ESCOLA | NECESSIDADES DO TIME |
| 1 | CLEVELAND | DE/OLB (3-4) | Myles Garrett | TEXAS A&M | DL, QB, OL, DB, LB |
| 2 | SAN FRANCISCO | DE | Solomon Thomas | STANFORD | QB, DL, DE/OLB |
| 3 | CHICAGO | SS | Jamal Adams | LSU | DB, DL, QB, WR |
| 4 | JACKSONVILLE | DL | Jonathan Allen | ALABAMA | QB, RB, S, DL |
| 5 | TENNESSEE (FROM RAMS) | CB | Marshon Lattimore | OHIO STATE | DB, WR, pass rush (3-4) |
| 6 | NEW YORK JETS | QB | Mitchell Trubisky | NORTH CAROLINA | QB, DB, OL, TE |
| 7 | LOS ANGELES CHARGERS | S | Malik Hooker | OHIO STATE | OL, RB, WR, LB |
| 8 | CAROLINA | RB | Leonard Fournette | LSU | RB, OL, DB, DE |
| 9 | CINCINNATI | OLB | Takkarist McKinley | UCLA | OL, DT/LB, CB |
| 10 | BUFFALO | WR | Mike Williams | CLEMSON | WR, OL/QB, LB, DL |
| 11 | NEW ORLEANS | DE | Derek Barnett | TENNESSEE | DB, DE, DET/LB, RB |
| 12 | CLEVELAND (FROM PHI) | TE | O.J. Howard | ALABAMA | DL, QB, OL, DB, LB |
| 13 | ARIZONA | QB | Deshaun Watson | CLEMSON | QB, S/CB, ILB, TE |
| 14 | PHILADELPHIA (VIA MIN) | RB | Christian McCaffrey | STANFORD | DB, RB, DL, WR |
| 15 | INDIANAPOLIS | ILB | Reuben Foster | ALABAMA | LB, RB, S/LB, OL |
| 16 | BALTIMORE | WR | Corey Davis | WESTERN MICHIGAN | WR, OT, OLB (3-4), DB |
| 17 | WASHINGTON | RB | Dalvin Cook | FLORIDA STATE | DL, CB, RB, WR |
| 18 | TENNESSEE | WR | John Ross | WASHINGTON | DB, WR, Pass Rush (3-4) |
| 19 | TAMPA BAY | TE | David Njoku | MIAMI (FL) | S. OT, DL, TE/WR |
| 20 | DENVER | OT | Ryan Ramczyk | WISCONSIN | OL, DT, TE |
| 21 | DETROIT | DE/OLB | Charles Harris | MISSOURI | CB, DE, LB, RB |
| 22 | MIAMI | G | Forrest Lamp | WESTERN KENTUCKY | G, DE/OLB (4-3), DB |
| 23 | NEW YORK GIANTS | ILB | Haason Reddick | TEMPLE | DL, LB, OL/RB, TE |
| 24 | OAKLAND | CB | Gareon Conley | OHIO STATE | DB, RUSH D, RB |
| 25 | HOUSTON | OT | Cam Robinson | ALABAMA | QB, WR, CB, DT |
| 26 | SEATTLE | OT | Garett Bolles | UTAH | OL/OT, DT, CB |
| 27 | KANSAS CITY | QB | DeShone Kizer | NOTRE DAME | DL,, OLB, ILB, WR, QB (?) |
| 28 | DALLAS | CB | Kevin King | WASHINGTON | DB, DL, TE |
| 29 | GREEN BAY | OLB | T.J. Watt | WISCONSIN | CB, LB, RB, G |
| 30 | PITTSBURGH | EDGE | Tyus Bowser | HOUSTON | S, CB SLOT, DT, RB, EDGE |
| 31 | ATLANTA | DE | Taco Charlton | MICHIGAN | DE;OLB, DT, LB/S, G |
| 32 | NEW ORLEANS (VIA NE) | CB | Marlon Humphrey | ALABAMA | DB, DE, DET/LB, RB |
